Ubiquinol is the reduce form i.e. negatively charged form of CoQ10 whereas ubiquinone is the oxidized form i.e. positively charged form of CoQ10. Cells within the body perform the redox interconversion reaction to maintain a state of equilibrium between the two forms as needed. This means that if there are insufficient levels of ubiquinol then increased amounts of ubiquinone will be reduced to form ubiquinol. Ubiquinol, due to its complete reduction get an increased polarity of the molecule thus shows a significant factor behind the enhanced bioavailability. The significant increase in plasma CoQ10 status observed after the 2-weeks supplementation suggested that ubiquinol appeared to be a better supplemental form to enhance the CoQ10 status than ubiquinone in older men- Food Funct.
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